Dependence of Alamethicin Membrane Orientation on the Solution Concentration
نویسندگان
چکیده
منابع مشابه
Lipid-alamethicin interactions influence alamethicin orientation.
Whereas the barrel-stave configuration is accepted by most investigators as a good description of the conducting state of alamethicin, there are conflicting interpretations on its nonconducting state; in the absence of an applied field, some found alamethicin molecules on the membrane surface, but others found them incorporated in the hydrophobic core of the membrane. This problem is resolved b...
متن کاملSigmoidal concentration dependence of antimicrobial peptide activities: a case study on alamethicin.
The transition of the state of alamethicin from its inactive state to its active state of pore formation was measured as a function of the peptide concentration in three different membrane conditions. In each case the fraction of the alamethicin molecules occupying the active state, phi, showed a sigmoidal concentration dependence that is typical of the activities of antimicrobial peptides. Suc...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry C
سال: 2013
ISSN: 1932-7447,1932-7455
DOI: 10.1021/jp3099522